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| Otobone,Fernanda Jacques; Sanches,Andréia Conegero; Nagae,Rosangela Lika; Martins,Juliana Vanessa Colombo; Obici,Simoni; Mello,João Carlos Palazzo de; Audi,Elisabeth Aparecida. |
| The effect of crude lyophilized extract (EBPC) and the semi-purified constituents (EPA and EPB) of Paullinia cupana (guaraná) seeds long-term administered in rats by gavage at different doses was studied on cognitive behavior in rats. EBPC (30.0 mg/kg) and EPA (2.0 mg/kg), but not EPB (2.0 or 4.0 mg/kg) showed a smaller escape latency to find the emerged platform in Morris water maze test (MWMT), showing nootropic-like effect in normal rats, and in scopolamine induced amnesia rats compared to their controls (saline + 0.2% Tween 80) group. These extracts had no significant effect in open field test (OFT). Caffeine did alter escape latency in MWMT only in scopolamine induced amnesia rats and increased the crossings number in OFT, showing significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cognitive effects; Guaraná; Morris water maze; Paullinia cupana. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000600007 |
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| Angelucci,M.E.M.; Cesário,C.; Hiroi,R.H.; Rosalen,P.L.; Cunha,C. Da. |
| We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P<=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Memory; Learning; Caffeine; Methylxanthines; Adenosine receptor antagonist; Morris water maze. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013 |
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